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A patient asks the nurse why a lower dose of IV pain medication is being given than the previous oral dose. What is the nurse's best response to the patient? A) "A large percentage of an intravenously administered drug is metabolized into inactive metabolites in the liver."B) "Medications given intravenously are not affected by the first-pass effect."C) "Drugs administered intravenously enter the portal system before systemic distribution."D) "Medications given orally bypass the portal circulatory system."

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