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Les filaments intermédiaires présents dans les cellules nerveuses sont constitués de protéines qui varient en fonction du stade de développement et du type de cellule nerveuse. Ainsi on trouve la nestine dans les cellules souches neuroépithéliales. La périphérine est présente dans les cellules du système nerveux périphérique. Les neurofilaments de type L, M et H sont présents dans tous les neurones du système nerveux central et du système nerveux périphérique alors que la GFAP ne s'exprime que dans les astrocytes.Le réseau des filaments intermédiaires est particulièrement abondant dans l'axone des neurones moteurs car ils jouent un rôle clé dans le soutien mécanique de ces longs et fins prolongements qui peuvent atteindre plus d'un mètre.

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