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La stabilité des microtubules peut aussi être régulée par la présence de protéines accessoires que l'on appelle MAP pour Microtubule-Associated Proteins. Ces protéines peuvent stabiliser les microtubules et s'opposer au désassemblage. Les MAP possèdent un domaine qui se lie latéralement à la surface du microtubule et une région qui se projette vers l'extérieur. Ce bras permet d'établir des contacts avec le microtubule voisin mais varie en longueur selon la protéine

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