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i l'on compare la protéine MAP2 et la protéine Tau qui différent par le domaine qui se projette à l'extérieur on comprend que l'espacement entre 2 microtubules peut être plus petit pour Tau que pour MAP2. Ceci a été démontré expérimentalement dans des axones dans lesquels on a surexprimé l'une ou l'autre de ces protéines accessoires. On voit que la disposition des microtubules est plus serrée avec la protéine Tau qu'avec la protéine MAP2.

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