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Cette organisation donne une architecture à la cellule et consolide le tissu épithélial en lui conférant une résistance mécanique ce qui a été démontré dans une maladie génétique appelée l'épidermolyse bulleuse héréditaire, apparition de bulles sur les zones de frottement même lorsque les frottements sont mineurs comme on peut le voir sur la plante du pied de ce patient. L'observation de cette lésion sur une coupe histologique montre la rupture de l'épithélium avec un décollement entre les couches stratifiées de l'épiderme.

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