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'attachent aux jonctions intercellulaires comme les desmosomes par l'intermédiaire de la desmoplakine et de la plakoglobine qui sont des protéines accessoires. Les cytokératines tendent des haubans avec les hémidesmosomes qui sont les points de contacts avec la matrice extracellulaire. Enfin les filaments intermédiaires sont également attachés à l'enveloppe nucléaire et forment un réseau en forme de cage autour du noyau. Ils participent ainsi au positionnement des organites.

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