Biochemistry Questions
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The cleavage of argininosuccinate to arginine involves this TCA intermediate A. Succinate B. Oxaloacetate C. Fumarate D. Alpha ketoglutarate
Glucogenic amino acids are utilized as substrate for A. Anaerobic respiration B. Fatty acid synthesis C. Gluconeogenesis D. None of the above
In the mechanism of all transaminases, the pyridoxal phosphate A. becomes reduced and the amino acid is oxidized B. receives the amine group through a Schiff's base reaction C. becomes carboxylated D. All of the above
Alanine is transported from the skeletal muscle to liver to be back converted to pyruvate. The pyruvate in the liver is then used for A. Glycolysis B. Homolactic Fermentation C. Gluconeogensis D. Fatty Acid synthesis
The source of the first NH3+ for the formation of carbamoyl phosphate in the mitochondria is aspartate. A. True B. False
What is the difference between essential and non-essential amino acids? A. Essential amino acids are synthesized by liver cells; non-essential amino acids are not needed in the body and cells can do without them B. Essential amino acids are made by liver cells; non-essential amino acids cannot be produced by the liver and are obtained from diet C. Non-essential amino acids are produced in the liver; essential amino acids are produced in all cells by metabolic pathways D. Essential amino acids are obtained from diet; non-essential amino acids are produced in the liver by metabolic pathways
Both serine and threonine are directly deaminated to A. Alpha ketoglutarate B. Acetyl-CoA C. Pyruvate D. Oxaloacetate
The transamination of oxaloacetate forms A. Glutamate B. Threonine C. Aspartate D. Asparagine
The serine-glycine complex plays a role in A. Adenylation of methionine to S-adenosyl-methionine B. Formation of cysteine through transcultural ion pathway C. Remethylation of MTHF for the remethylation of homocysteine to methionine D. Methylation of macromolecules by S-adenosyl-methionine
Which statement about cysteine is NOT correct? A. Cysteine is a sulfur-containing amino acid B. Homocysteine is metabolized by the transulfuration pathway to cysteine C. Cysteine can be remethylated to form methionine D. Cysteine is a non-essential amino acid
Decarboxylated AdoMet becomes a donor of A. Methyl groups to macromolecules B. Adenosine for the salvage pathway C. Aminopropyl donor to form larger polyamines D. All of the above
The remethylation of homocysteine to methionine requires which two cofactors? A. N5,N10-methylene & B6 B. FAD & B12 C. N5,N10-methyleneTHF & B12 D. B2 & B6
Glutamate is aminated to glutamine by the enzyme A. Glutamate dehydrogenase B. Glutaminase C. Glutamine synthetase D. Glutamine oxidase
When glutamate donates an amine group to pyruvate, which amino acid is formed? A. Alanine B. Aspartate C. Proline D. Serine
The biochemical function of AdoMet is A. Oxidation of enzymes B. Methylation of macromolecules C. Methlyation of nucleic acids only D. Methylation of tetrahdyrofolate
A Schiff's base mechanism takes place during the transaminase reaction. Which of the following statements correctly describes this mechanism? A. An active site lysine residue is aminated by the incoming amino acid forming the first keto acid, which is then released as a product B. Biotin is aminated in the active site of the transaminase by the incoming first amino acid to produce the first keto acid released as a product C. Pryidoxal phosphate in the active site of the transaminase is aminated forming pyridoxamine from the first amino acid, then the first keto acid is released D. A lysine residue becomes protonated in the active site, which causes the first amino acid to directly aminate the first keto acid to the new amino acid
The product of S-adenosyl-methionine methylation is S-adenosyl -homocysteine, which is then de-adenylated. How is the cleaved adenosine utilized? A. Utilized to re-adenylation of methionine B. Recycled to ATP C. Adenosine is excreted D. Purine salvage pathway
Glucogenic amino acids are utilized in the gluconeogenic pathway of the liver. A. True B. False
Glutamate is back converted to alpha ketoglutarate in liver mitochondria by A. Glutaminase B. Glutamate synthase C. Glutamate dehydrogenase D. All of the above
The cofactor found in the active site of ALL transaminase enzymes is A. Cobalamin phosphate B. Pyridoxal phosphate C. Ferrodoxin D. Biotin